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Pfizer Oncology
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The safety and efficacy of this agent(s), or use in this setting, has not been established or is subject to confirmation. For an agent(s) whose safety and efficacy has not been established or confirmed, future regulatory approval or commercial availability is not guaranteed.

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Important Notice: The information provided here relates to investigational therapies. The safety and efficacy of these investigational therapies has not been proven.

Poster

Symbiotic-GI-03: a randomized, double-blind, phase 3 study of first-line PF-08634404, a PD-1/VEGF bispecific antibody, in combination with mFOLFOX6 in patients with metastatic colorectal cancer (mCRC)

Cathy Eng, Elena Élez, Julien Taieb, Rui-Hua Xu, Hiroya Taniguchi, Tanios S. Bekaii-Saab, Jeanne Tie, Myriam Chalabi, Zhiyu Chen, Aman Opneja, Mark D. Kochenderfer, Yong Sang Hong, Donald A. Richards, Barbara Radecka, Yiyi Chen, Jill Clancy, Svitlana Tonkovyd, Xiaosong Zhang, Kimmie Ng

PD-1 x VEGF Bispecific Antibody | May 30, 2026 | ASCO 2026

C6461003 | NCT07222800

Poster

A phase 3 trial of a PD-1/VEGF bispecific antibody (PF-08634404) vs pembrolizumab in combination with platinum-based chemotherapy in first-line for locally advanced or metastatic non-small cell lung cancer (Symbiotic-Lung-01)

David Planchard, Martin Reck, Rachel Roberts-Thomson, Vishal Navani, Caicun Zhou, Filippo de Marinis, Akito Hata, Yasushi Goto, Noelia Vilarino, Enriqueta Felip Luis Paz-Ares, Yang Chih-Hsin, Jhanelle E. Gray, Smitha Menon, Matthew Mirsky, Kevin Kim, Matteo Setti, Melissa Johnson

PD-1 x VEGF Bispecific Antibody | March 25, 2026 | ESMO ELCC 2026

C6461001 | NCT07222566